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Persistent sad, anxious, or "empty" mood |
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Feelings of hopelessness, pessimism |
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Feelings of guilt, worthlessness, helplessness |
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Loss of interest or pleasure in hobbies and activities that were once enjoyed, including sex |
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Decreased energy, fatigue, being "slowed down" |
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Difficulty concentrating, remembering, making decisions |
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Trouble sleeping, early-morning awakening, or oversleeping |
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Appetite and/or weight changes |
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Thoughts of death or suicide, or suicide attempts |
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Persistent physical symptoms, such as headaches, digestive disorders, and chronic pain, which do not respond to routine treatment |